These are the most common areas for users to want to customise EndNote to suit their requirements. EndNote comes with thousands of 'content files' to cater for users, from all areas of research, with a wide range of referencing requirements straight out of the box. There is also the opportunity to download additional files from the Thomson Reuters web site. However, there are numerous reasons why user would want to create new 'content files'.

Historically there were three packages on the market, helping users manage their references and write their papers: Procite; Reference Manager; and EndNote. Thomson Reuters owned all three and eventually decide to withdraw Procite, leaving the other two. Recently they announced that Reference Manager was going to be retired too.